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The main reasons for exclusion were that the research described was not an RCT; that the study evaluated skin rather than nasal mupirocin, that the study reported elimination rather than infection data or that the intervention involved a combination of several interventions.
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Conversion of Staphylococcus epidermidis strains from commensal to invasive by expression of the ica locus encoding production of biofilm exopolysaccharide.
Most cases of superficial cellulitis improve within one day, but patients who exhibit thickening of the dermis usually take several days of parenteral antibiotics before significant improvement occurs.
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Cream is as good as the ointment for treating the above indications and is cosmetically more acceptable.
So, the duration of treatment seems appropriate.
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In the IPPR study, an elevated relapse rate (23%) was noted when, based on culture and in vitro susceptibility results, patients were switched to monotherapy with a first-generation cephalosporin rather than to other final monotherapies or combination therapies ().
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