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Dolutegravir concentrations also are decreased by coadministration of rifampin; doubling the dosage of dolutegravir results in plasma concentrations comparable to those seen without rifampin.
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However, the trial patients are likely to be more acutely unwell than patients with tuberculosis and may require closer monitoring; additional tests may be requested at any time where necessary for patient management.
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However, the UDP-GA contents were decreased less effectively by piperine in isolated rat hepatocytes compared with enterocytes of guinea pig small intestine.
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This contrasts with the typical tetracyclines, which interact with the ribosome to inhibit bacterial protein synthesis and display a reversible bacteriostatic effect.
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The nitrate reductase assay (NRA) has been proposed as a rapid method for the detection of resistance to rifampicin and isoniazid, but its accuracy has not been systematically evaluated.
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